Rar alpha genecards

Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes PubMed In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression PubMed On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation PubMed, PubMed, PubMed RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis By similarity.

Has a role in the survival of early spermatocytes at the beginning prophase of meiosis By similarity. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes By similarity. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function By similarity. Interacts with CDK7 By similarity. Predicted three dimensional structure from AlphaFold P Phosphorylation does not change during cell cycle.

Phosphorylation on Ser is crucial for transcriptional activity By similarity. Phosphorylation by AKT1 is required for the repressor activity but has no effect on DNA binding, protein stability nor subcellular localization. Phosphorylated by PKA in vitro. This phosphorylation on Ser and Ser is critical for ligand binding, nuclear localization and transcriptional activity in response to FSH signaling.

Summary Go to the top of the page Help. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes.

Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.

Genomic context Go to the top of the page Help. Annotation release Status Assembly Chr Location Genomic regions, transcripts, and products Go to the top of the page Help. Go to reference sequence details. Expression Go to the top of the page Help.

See details. Bibliography Go to the top of the page Help. Li J, et al. Biochem Biophys Res Commun, Jul Xiong L, et al. Cell Signal, Jan. Wang Z, et al. Pediatr Surg Int, Aug. O : Transcription intermediary factor 1-alpha; TIF1-alpha; 6. O : Histone deacetylase 3; HD3; 3. O : Lysine-specific demethylase hairless; 1. CMHD 4. O : Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 2. P : Transcription factor Sp1. P0CW22 : 40S ribosomal protein Slike. P : Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta.

P : DNA topoisomerase 1; 5. P : Ski oncogene; Proto-oncogene c-Ski. P : Proto-oncogene tyrosine-protein kinase Src; 2. P : X-ray repair cross-complementing protein 6; 3. P : X-ray repair cross-complementing protein 5; 3. CMHD 3.

P : Transcription factor PU. P : Cyclin-dependent kinase 11B; 2. P : Nucleolin; Protein C CMHD 4. P : Dual specificity protein phosphatase 1; 3. P : Lysine-specific demethylase 5A; 1. P : Heme oxygenase 2; HO-2; 1. P : protein sigma; Epithelial cell marker protein 1; Stratifin. P : Signal transducer and activator of transcription 3; Acute-phase response factor.

P : Signal transducer and activator of transcription 6; IL-4 Stat. P : Signal transducer and activator of transcription 5A. P : Collagenase 3; 3. P : Transcription activator BRG1; 3. P : Succinate-semialdehyde dehydrogenase, mitochondrial; 1. P : Signal transducer and activator of transcription 5B. P : E3 ubiquitin-protein ligase TTC3; 6. EntrezGene 3. GeneCards 3.

CMHD 2.